You can participate in this study if you are currently between 8 and 10 weeks pregnant of one baby and you are at risk for spontaneous preterm labor because either:

• You had a sPTB during a previous pregnancy, defined as a delivery between 24 and 37  weeks

• Your previous pregnancy was complicated by premature  rupture of membranes before 37 weeks

• You had a spontaneous second-trimester pregnancy loss between 14 and 24  weeks during previous pregnancy

 

To participate in this study, you may not meet one or more of the following criteria:

• You already use pro-, pre- or synbiotics

• You are pregnant with more than one baby

• You underwent a primary (type 1) cerclage (= a stitch through the cervix, which is placed to prevent the cervix from shortening and opening too early during pregnancy)

• You suffer from a disease in which the intestines are inflamed (e.g. Crohn's disease or ulcerative colitis)

• You have a known congenital uterine defect

• You have a history of cervical conization, a procedure in which a cone-shaped, abnormal piece of tissue is removed from the cervix

 

The investigator or study staff will discuss with you if you are eligible to participate into the study.